Project 9

A roadmap to personalized medicine for sepsis therapy by investigation a correlation between biomarkers and severity of sepsis

Host institute: Uppsala Universitet, Sweden (UU)
Supervisor: Dr Stephanie Franzén
Co-supervisor: Kris van Assche (5D)

1. To investigate and proof the application of these validated drug targets (Work Package 2) as biomarkers.
2. To find a correlation between the levels of these biomarkers in blood of sepsis patients with the severity.

Expected Results
1. Identify new biomarkers (new histone isotypes) and proof the validated drug targets (HMGB1, histones, PAD2/4) can also be utilized as biomarkers for sepsis diagnosis.
2. A profile of a correlation between the levels of these biomarkers in blood and the severity of sepsis in each individual patient.

- WWU (3 months)
- IIBB (3 months)

Qualifications: Master in Science (MSc) or Medical Doctor degree (MD) equivalent to 240 credits, Felasa C certificate (or equivalent), English B2 or above. The chosen applicant will be processed through the university application system and require the institution board approval prior to acceptance for doctoral studies.
Experience: Minimum of four years undergrad studies within the field of biomedicine, medicine, or cell biology. The applicant should have experience in different basic methodology within the research field.
Knowledge & skills: The applicant should have basic knowledge in how to conduct in vivo experiments on animal models and knowledge in basic statistics. Good knowledge in standard in vitro analytical methods is meritorious (PCR, Western, ELISA, etc). Experience in experimental large animal models or clinical studies is commendable. Good Clinical Practise (GCP) and Good Laboratory Practise (GLP) course certificate are highly meritorious.
Abilities: In abundance to the aforementioned requirements, the applicant should possess the ability to successfully conduct literature studies i.e., retrieve, critically review, analyze, and summarize literature. The applicant should be fluent in English in both writing and speech and have good communication abilities. The ability to independently plan experimental studies is meritorious.
Attitude and disposition: The Praetorian MSCA doctoral network requires abundant traveling and social settings. The applicant should be willing to present research orally and in writing, socialize and network at meetings within the consortium but also at major international conferences and at the home institution. The applicant is expected to voluntary contribute to the science community including engaging in scientific communities and PhD-communities at Uppsala University.